Adding a certain compound to certain chemical reactions, such as: 97165-77-0, name is 3,5-Dibromobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97165-77-0, Quality Control of 3,5-Dibromobenzonitrile
3,5-dibromobenzene cyanide (20.0 mmol) under nitrogen protection,1-THP-4-pyrazoleboronic acid pinacol ester (48.0 mmol) and 1,4-dioxane (120 mL) and water (30 mL) were added to a 250 mL round bottom flask.Add magnetron stirring, then add K2CO3 (60.0mmol)And Pd(PPh3)4 (1.0 mmol), the reaction was stirred at 100 C for 24 hours. After the reaction is completed, the solvent of the reaction system is spin-dried.The residue was dissolved in ethyl acetate (200 mL).Wash with water (150 mL × 2) and saturated brine (200 mL),After drying over anhydrous Na 2 SO 4 , filtered and concentrated.The crude product was purified by column chromatography (SiO2, petroleum ether / ethyl acetate = 20:1 to 1:1).After concentration, 3,5-bis(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenyl cyanide was obtained as a pale yellow solid (yield: 84%).
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Reference:
Patent; Beijing University of Technology; Li Jianrong; Kong Xiangjing; Zhang Yongzheng; He Tao; (10 pag.)CN109851559; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts