Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 71825-51-9, name is 2-Methyl-2-(4-nitrophenyl)propanenitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Methyl-2-(4-nitrophenyl)propanenitrile
16 g (84.1 mmol) of 2-methyl-2-(4-nitro-phenyl)-propionitrile (Example Id) and 4.16 g of Raney-Ni are shacked in 160 ml of THF-MeOH (1: 1) under 1.1 bar of H2for 12 h. at RT. After completion of the reaction, the catalyst is filtered-off and the filtrate is evaporated to dryness. The residue is purified by flash chromatography on silica gel (hexane-EtOAc 3: 1 to 1:2) to provide the title compound as an oil. ES-MS: 161 (M + H)+; analytical HPLC: tret= 2.13 minutes (Grad 1).
The synthetic route of 71825-51-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo; WO2013/23119; (2013); A1;,
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