Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6621-59-6, name is 6-Bromohexanenitrile, A new synthetic method of this compound is introduced below., Product Details of 6621-59-6
General procedure: To a magnetically stirred solution of 131 mg isoindigo 1(0.5 mmol) in 3 cm3 DMF, 59.4 mg sodium methoxidesolution (1.1 mmol) was added in 2 cm3 DMF at roomtemperature. The reaction mixture stirred for 30 min, followedby the addition of the alkyl bromide (3 mmol) andthe reaction stirred for 6 h at 45 C. The mixture waspoured into 10 cm3 H2O, extracted with 20 cm3 CH2Cl2,dried (MgSO4), and the solvent was removed underreduced pressure. The residue was subjected to silica gelcolumn chromatography using hexane-ethyl acetate aseluent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Khalili, Gholamhossein; Willis, Anthony C.; Keller, Paul A.; Monatshefte fur Chemie; vol. 149; 11; (2018); p. 2103 – 2111;,
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