Application of 10412-93-8, These common heterocyclic compound, 10412-93-8, name is N-Benzyl-2-cyanoacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5.6. Synthesis Of (E)-2-(benzylaminocarbonyl)-3-(3-iodo-4,5-dihydroxyphenyl)acrylonitrile A preferred method of synthesis of (E)-2-(benzylaminocarbonyl)-3-(3-iodo-4,5-dihydroxyphenyl)acrylonitrile (Compound 6) is as follows: A mixture of 0.4 g of 2-cyano-3-(4-hydroxy-3-iodo-5-methoxy)phenylacrylonitrile (which was prepared by condensation of 4-hydroxy-3-iodo-5-methoxybenzaldehyde with N-benzylcyanoacetamide) and 0.5 ml of BBr3 in 20 ml dichloromethane was stirred for 2 hours at room temperature. Workup (H2 O, ethyl acetate) gave 0.16 g of a yellow solid (41 yield) having a melting point of 220 C. The product gave the following analytical data: NMR (acetone-d6) delta 8.05(1H,S,vinyl), 7.85(1H,d,J=2.1 Hz), 7.70(1H,d,J=2.1 Hz), 7.30(5H,in), 4.6(2H,S).
Statistics shows that N-Benzyl-2-cyanoacetamide is playing an increasingly important role. we look forward to future research findings about 10412-93-8.
Reference:
Patent; Sugen, Inc.; Yissum Research Development Co. of the Hebrew University of Jerusalem; US5792771; (1998); A;,
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