Synthetic Route of 13388-75-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Preparation of (2Z)-2-(3,5-dimethoxyphenyl)-3-{4-[(8-hydroxyoctyl)oxy]phenyl}prop-2-enenitrile 5.0 g (20.0 mmol) of 4-[(8-hydroxyoctyl)oxy]benzaldehyde, 3.5 g (19.8 mmol) of 3,5-(dimethoxyphenyl)acetonitrile are dissolved in 50 mL of propan-2-ol. The solution is heated to 60 C. and 2.0 mL (2.0 mmol) of a one molar solution of tetrabuthylamoniumhydroxyde in methanol are added drop wise. After 2 h at 60 C., the reaction mixture is cooled to 0 C. The precipitate is filtered off, washed with cold propan-2-ol and recristalized in propan-2-ol. 3.5 g of (2Z)-2-(3,5-dimethoxyphenyl)-3-{4-[(8-hydroxyoctyl)oxy]phenyl}prop-2-enenitrile are obtained as a white solid (42% yield). This material proves chromatographically homogenous and displays spectral characteristics consistent with its assigned structure. 1H NMR DMSO-d6 300 MHz: 7.99 (s, 1H), 7.94 (d, 2H), 7.09 (d, 2H), 6.86 (d, 2H), 6.56 (t, 1H), 4.32 (t, 1H), 4.05 (t, 2H), 3.81 (s, 6H), 3.37 (q, 2H), 1.73 (qi, 2H), 1.43-1.29 (m, 10H)
The synthetic route of 2-(3,5-Dimethoxyphenyl)acetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ROLIC AG; Lincker, Frederic; Bury S. Pires, Izabela; Chappellet, Sabrina; Scandiucci De Freitas, Patricia; Ibn-Elhaj, Mohammed; Tang, Qian; Palika, Satish; Hoshino, Masato; Eckert, Jean-Francois; (61 pag.)US9366906; (2016); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts