Reference of 127946-77-4,Some common heterocyclic compound, 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, molecular formula is C4H7ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a suspension ofcompound 18 (167 mg, 1.0 mmol) in1,2-dichloroethane (8 mL), either aminoacetonitrile hydrochloride (for 30; 102 mg, 1.1 mmol) or1-aminocyclopropane-1-carbonitrile hydrochloride (for 31; 130 mg, 1.1 mmol) was added at room temperature. After 5 min,DIPEA (192 muL, 1.1 mmol) was added, followed by the slow addition of Na(OAc)3BH(276 mg, 1.3 mmol). The reaction mixture was then left to stir at roomtemperature overnight. Then, CH2Cl2 (30 mL) was added andthe mixture extracted with saturated aqueous solution of NaHCO3 (40mL). The aqueous phase was further washed with CH2Cl2 (2×50 mL), the combined organic layers were dried with anhydrous Na2SO4,filtered, and evaporated under reduced pressure. Both compounds were purifiedby flash column chromatography.
The synthetic route of 127946-77-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sosi?, Izidor; Mitrovi?, Ana; ?uri?, Hrvoje; Knez, Damijan; Brodnik ?ugelj, Helena; ?tefane, Bogdan; Kos, Janko; Gobec, Stanislav; Bioorganic and Medicinal Chemistry Letters; vol. 28; 7; (2018); p. 1239 – 1247;,
Nitrile – Wikipedia,
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