Electric Literature of 5332-06-9, A common heterocyclic compound, 5332-06-9, name is 4-Bromobutanenitrile, molecular formula is C4H6BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 34-(benzylamino)butanenitrileBenzylamine (5.02 mL, 46 mmol) and calcium carbonate (23.65 g, 171.12 mmol) dissolved in anhydrous acetonitrile (115 mL) were stirred for 10 minutes at room temperature. After adding 4-bromonitrile (4.78 mL, 48.3 mmol), reaction was carried out at 100 C. for 2 days. A target compound (6.69 g, 38.395 mmol, 83.5%) was yielded as liquid by separating the reaction mixture in the same manner as Reference Example 1.1H NMR (CDCl3, 300 MHz) delta 7.37-7.29 (m, 5H), 3.79 (s, 2H), 2.77 (t, J=6.6 Hz, 2H), 2.48 (t, J=7.1 Hz, 2H), 1.88-1.79 (m, 2H).
The synthetic route of 5332-06-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Korea Institute of Science and Technology; US2011/319619; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts