These common heterocyclic compound, 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 3672-47-7
In a 15 mL reaction tube, add 1c (52.6 mg, 0.3 mmol), 1,2-dichloroethane (DCE, 1 mL), 2-methyl-4-phenyl-3-butyn-2-ol (2a , 72.1mg, 0.45mmol),Dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer ([RhCp * Cl2] 2, 13.0mg, 0.021mmol) and CsOAc (57.6mg, 0.3mmol) will react in the air atmosphere The tube was sealed and the reaction was stirred at 100 C for 24 h. After the reaction was completed, the reaction tube was cooled to room temperature, suction filtered, and the mother liquor was spin-dried with silica gel and separated through a silica gel column (petroleum ether / ethyl acetate = 10/1) to obtain 3c (61.8 mg, 65%) as a yellow solid.
The synthetic route of 3-(4-Methoxyphenyl)-3-oxopropanenitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Henan Normal University; Fan Xuesen; Song Xia; Zhang Xinying; (24 pag.)CN110746319; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts