Application of 3759-28-2, These common heterocyclic compound, 3759-28-2, name is 2-(Cyanomethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
100ml of water was added to the reaction vessel, 20mmol (o-cyanophenyl)acetonitrile, 40mmol of potassium (m-tolyl)trifluoroborate 0.4mmol palladium acetylacetonate, 0.8mmol nitrogen ligands L-1, and p-toluenesulfonic acid monohydrate 100mmol, in The reaction was stirred at 60 deg.] C for 30 hours.AntiAfter should be ended, the mixture was poured into ethyl acetate, sequentially with saturated NaHCO3solutionand brine, the aqueous layer was extracted with ethyl acetate, the organic layers combined (i.e., combined washedorganic layer and the extract obtained the organic layer), dried over anhydrous of Na2the SO4dried, vacuum is removed by evaporationof the solvent, the residue was purified by flash column chromatography (hexane / ethyl acetate, volume ratio of between1: 1) to give the target liquid product.The yield was 72.5%,% purity was 99.1(the HPLC).
The synthetic route of 3759-28-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wenzhou University; CHEN, JIUXI; LIU, MIAOCHANG; CHENG, TIANXING; WANG, XIAODONG; GAO, WENXIA; HUANG, XIAOBO; WU, HUAYUE; (14 pag.)CN104557701; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts