In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 56043-01-7 as follows. Safety of 2-Amino-6-methylbenzonitrile
Example 1: n-Propyl- (2-cyano-3-methyl-phenyl) sulfonamide 1.1 : 2-Cyano-3-methyl-phenylsulfonylchloride; A solution of 11.6 g (88 mmol) of 2-amino-6-methylbenzonitrile (prepared, e. g. accord- ing to WO 94/18980) in 120 ml of glacial acetic acid was initially charged and 32.2 g of concentrated hydrochloric acid were slowly added at room temperature. The reaction mixture was stirred at room temperatures for 10 minutes and then a solution of 6.4 g (92 mmol) of sodium nitrite in 20 ml of water was added dropwise at 5-10C. The reac- tion mixture was stirred at 0C for one hour to obtain the diazonium salt. In a separate stirred flask, a saturated solution of sulfur dioxide in glacial acetic acid was prepared at 10C and a solution of 5.5 g of copper ( . t) chloride in 11 ml of water was added. The reaction mixture of the diazonium salt which had been prepared beforehand was then added dropwise to the solution of the copper salt. The resulting mixture was stirred at room temperature for additional 45 minutes. Then the reaction mixture was poured into ice-cooled water and the aqueous phase was extracted three times with dichloro- methane. The combined organic layers were dried over a drying agent and filtered. The filtrate was concentrated in vacuo to afford 16.4 g (87% of the theory) of the title com- pound having a melting point of 75-77C.
According to the analysis of related databases, 56043-01-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BASF AKTIENGESELLSCHAFT; WO2005/35486; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts