Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50670-64-9, name is 5-Amino-2-methylbenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 50670-64-9
General procedure: A mixture of compound 2 (1.82 g, 8.8 mmol) and DMF (30 drops) in SOCl2 (50 mL) was refluxed for 7 h. The excess SOCl2 was removed by vacuum distillation. The residue was stirred with diethyl ether, filtered, washed, and dried to give compound 3 as a beige solid (1.83 g, 92%). A mixture of compound 3 and various amines in 2-propanol or DMF was refluxed. Upon completion of the reaction, it was cooled in an ice bath. The residue was filtered, washed, and dried to isolate the product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Yang, Su Hui; Khadka, Daulat Bikram; Cho, Suk Hee; Ju, Hye-Kyung; Lee, Kwang Youl; Han, Ho Jae; Lee, Kyung-Tae; Cho, Won-Jea; Bioorganic and Medicinal Chemistry; vol. 19; 2; (2011); p. 968 – 977;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts