Application of 75279-55-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 75279-55-9, name is 2-Chloro-6-fluorophenylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a cooed (0C) solution of suitable nitrile derivative (V) (1.0 eq) in EtOH (12.0 eq), acetyl chloride (8.0 eq) was added dropwise; the reaction flask was stoppered tightly and the reaction mixture was allowed to warm to r.t. and stirring was continued for 6 hrs at same temperature. Then the reaction was stopped, the solvent was removed under reduced pressure and the reaction mixture was cooled to 0C. Saturated NaHCO3 solution was added and the resulting mixture was stirred until gas evolution ceased. The product was extracted with Et2O and the organic solution was washed with H2O and brine. The organic layer was dried over anhydrous Na2SO4, filtered and evaporated under reduced pressure; the crude product was purified by CC over silica gel, using EP/EtOAc 3:1 v/v as the eluent, to afford the pure desired intermediate 4. (y = 35%)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-fluorophenylacetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AXXAM S.p.A.; PEVARELLO, Paolo; SODANO, Mariangela; SEVERI, Elda; VITALONE, Rocco; THOMAS, Russell; (98 pag.)EP3398941; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts