Adding a certain compound to certain chemical reactions, such as: 17417-09-3, name is 2-Fluoro-5-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17417-09-3, Recommanded Product: 2-Fluoro-5-nitrobenzonitrile
2-(1-Pyrrolidinyl)ethanol (770 mul_, 12.0 mmol) was injected into a 00C stirred suspension of 2-fluoro-5-nitrobenzonitrile (1.0 g, 6.0 mmol), 60% w/w NaH as a suspension in oil (361 mg, 9.0 mmol) and DMF (10 ml_). The ice bath was removed and the reaction was allowed to warm to rt. TLC confirmed consumption of the starting material and the DMF was removed under vacuum. The resulting residue was partitioned between EtOAc and water. The organic fraction was washed with brine and dried over MgSO4. The organic fraction was concentrated and purified by silica gel chromatography (gradient: 0-100%(90%CH2Cl2:9%MeOH:1%NH4OH)/CH2Cl2). Purification provided 330 mg (22%) of 5-nitro-2-{[2-(1-pyrrolidinyl)ethyl]oxy}benzonitrile. 1H NMR (400 MHz, DMSO-c/6) delta ppm 8.62 – 8.69 (m, 1 H), 8.47 (ddd, J = 9.3, 2.9, 0.9 Hz, 1 H), 7.46 (d, J = 9.3 Hz, 1
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-5-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/32667; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts