In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1885-29-6 as follows. Application In Synthesis of 2-Aminobenzonitrile
Bromine (3.52 g, 0.022 mol) was added dropwise to a magnetically stirred, cooled (ice-water bath) solution of 2-aminobenzonitrile 2 (1.18 g, 0.01 mol) in acetic acid (30 mL) at 15-20 C over 10 min. The reaction mixture was stirred at room temperature for 5 h, then added to ice-water (100 mL), and the white precipitate was collected by filtration. The precipitate was washed thoroughly with water, and dried on Na2SO4 at room temperature to afford a white solid mass 7 (98%), mp 155-156 C (Lit,26 156 C); Rf (30% EtAcO/hexane) 0.37. 1H NMR (300 MHz, CDCl3): delta 7.73 (d, 4J=2.3 Hz, 1 H), 7.48 (d, 4J=2.3 Hz, 1 H), 4.90 (br s, 2 H) ppm. 13C NMR (75 MHz, CDCl3): delta 146.4, 139.6, 133.8, 115.8, 109.9, 108.4, 98.1 ppm. All data were identical to that reported in the literature.26
According to the analysis of related databases, 1885-29-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ekiz, Makbule; Tutar, Ahmet; Oekten, Salih; Tetrahedron; vol. 72; 35; (2016); p. 5323 – 5330;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts