In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5414-21-1, name is 5-Bromovaleronitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 5-Bromovaleronitrile
In a four-neck reactor equipped with a thermometer, 5.00 g (30.3 mmol) of 2-hydrazinobenzothiazole was placed in a nitrogen stream, and dissolved in DMF 100 mL.To this solution was added 20.9 g (152 mmol) of potassium carbonate,5-bromovaleronitrile 5.17 g (30.3 mmol),Stir at 60 C for 8 hours.After the reaction was completed, the reaction liquid was cooled to 20 C, and the reaction liquid was poured into water of 500 mL.It was extracted with 500 mL of ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate.After sodium sulfate was filtered, ethyl acetate was distilled off under reduced pressure using a rotary evaporator to obtain a yellow solid. The yellow solid was recrystallized by hexane column chromatography (hexane: ethyl acetate = 60: 40) to yield 3.41 g of Intermediate J (yield: 45.7 mol%) as a white solid.
The synthetic route of 5414-21-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; (157 pag.)TW2018/35058; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts