In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5332-06-9 as follows. Product Details of 5332-06-9
To a stirred suspension of NaH (0.092g, 60% dispersion in mineral oil, 1.2 mmol) in THF (15 mL) at 0 C was added dropwise a solution of 4 (0.5 g, 1 mmol) in THF (15 mL). The mixture wasstirred 0 C for 10 min and then a solution of 4-bromobutyronitrile (0.34 g,0.228 mL, 1.2 mmol) in THF (5 mL) was added slowly. The mixture was allowed towarm to r.t. and stirred overnight. It was then cooled to 0 C and cold water(5 mL) was added very slowly and extracted with ethyl acetate (2 x 15 mL). Thecombined organic phase was washed with water (3 x 10 mL), brine (10 mL), driedover Na2SO4 and evaporated. The product 5 (0.56 g,92%) was obtained by column chromatography on silica gel using pet ether: ethylacetate as an eluents.
According to the analysis of related databases, 5332-06-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Pakhare, Deepali S.; Kusurkar, Radhika S.; Tetrahedron Letters; vol. 56; 44; (2015); p. 6012 – 6015;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts