Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C10H8N2
A mixture of 2,2′-(1,4-phenylene)diacetonitrile, 1-bromopyrrolidine- 2,5-dione (2.6 g, 14.73 mmol) benzoic peroxyanhydride (0.36 g, 1.47 mmol) in CCl4 (30 mL) was stirred at 75-80 C for 4 hours. A second reaction mixture of 2,2′-(1,4- phenylene)diacetonitrile (2.0 g, 12.81 mmol) 1-bromopyrrolidine-2,5-dione (2.279 g, 12.81 mmol) benzoic peroxyanhydride (0.310 g, 1.281 mmol) in CCl4 (30 mL) was stirred at 75- 80 C for 4 hours. The mixtures were combined, then concentrated. The residue was purified by flash chromatography (eluted by petroleum ether:ethyl acetate = 20:1 – 1:1) to afford 2-bromo-2-(4-(cyanomethyl)phenyl)acetonitrile (2.6 g, 11.1 mmol).1H NMR (400 MHz, CDCl3) delta ppm 7.32 (d, J = 8.2 Hz, 2H), 7.17 (d, J = 8.1 Hz, 2H), 5.23 (s, 1H), 3.51 (s, 2H).
According to the analysis of related databases, 622-75-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Nicholas David; BENOWITZ, Andrew B.; RUEDA BENEDE, Maria Lourdes; EVANS, Karen Anderson; FOSBENNER, David T.; KING, Bryan Wayne; LI, Mei; MILLER, William Henry; REIF, Alexander Joseph; ROMERIL, Stuart Paul; SCHMIDT, Stanley J.; WIGGALL, Kenneth; (1283 pag.)WO2017/216726; (2017); A1;,
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