Reference of 6011-14-9,Some common heterocyclic compound, 6011-14-9, name is 2-Aminoacetonitrile hydrochloride, molecular formula is C2H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under nitrogen protection100 g (523 mmol) of 4-trifluoromethylnicotinic acid and 600 mL of toluene were placed in a three-neck reaction flask with a reflux condenser and a constant pressure dropping funnel, and 125 g (1.05 mol) of SOCl2 was slowly added to the reaction flask at 0 C. It was refluxed at 120 C for 2.5 hours. The contents of the reaction flask were concentrated, and after cooling, 600 mL of THF was added. 100 g (1.08 mol) of aminoacetonitrile hydrochloride and 600 mL of toluene were placed in the previous reaction flask, and the reaction flask was cooled to 0 C to maintain the temperature, and 190 g (1.88 mol) of Et 3 N was slowly added. The reaction flask was reacted at 25 C for 10 hours, and then most of the THF solution was removed under reduced pressure, and water and ethyl acetate were added for extraction.After drying and concentrating the organic phase, 112 g (488 mmol) of the solid of flonicamid was obtained.The yield was 93.4%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Aminoacetonitrile hydrochloride, its application will become more common.
Reference:
Patent; Shanghai Heteng Fine Chemical Co., Ltd.; Chen Sheng; Shi Guancheng; Meng Haicheng; (10 pag.)CN108191749; (2018); A;,
Nitrile – Wikipedia,
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