Adding a certain compound to certain chemical reactions, such as: 17216-62-5, name is Diethyl 2-(2-cyanoethyl)malonate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17216-62-5, category: nitriles-buliding-blocks
(a) 4-Cyano-2(R,S)-alpha-naphthylmethylbutyric acid 2.13 g of 2-cyanoethylmalonic acid diethyl ester are added to a suspension of 0.48 g of sodium hydride dispersion in 25 ml of DMF. The reaction mixture is stirred for 2 hours at 80 and then, at room temperature, 1.77 g of alpha-chloromethylnaphthalene in 5 ml of DMF are added. The mixture is further stirred for 16 hours at 50 and then concentrated by evaporation. The residue is dissolved in ethyl acetate, washed with 0.1N hydrochloric acid and water, dried over sodium sulphate and concentrated by evaporation, leaving 2-cyanoethyl-alpha-naphthylmethylmalonic acid diethyl ester.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 2-(2-cyanoethyl)malonate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Ciba-Geigy Corporation; US4727060; (1988); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts