Application of 57381-34-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57381-34-7, name is 5-Chloro-2-fluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a stirred 00C solution of 1,1,1,3,3,3-Hexamethyldisilazane (63 mL, 0.3 mol) in dry diethyl ether was added dropwise n-Butyl lithium (2M in hexanes, 150 mL, 0.3 mol). A white suspension formed, to which was added 2-Fluoro-5-chlorobenzonitrile (21.0 g, 0.14 mol) over 5 min. The resultant orange mixture was allowed to warm to r.t. and stirred for 2h. The mixture was cooled to 00C and the reaction quenched by the addition of 3M HCl (aq.) (240 mL). The mixture was stirred for 0.5h before water (600 mL) was added. The purple organic layer was discarded and the aqueous layer basified to pH 14 with satd. NaOH (aq.). The aqueous layer was extracted with CHCI3 (5×100 mL) and the organic extracts dried over Na2SO4. Evaporation yielded the desired product as a yellow solid (16.2g, 73% yield).
The synthetic route of 5-Chloro-2-fluorobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2008/40778; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts