Reference of 5866-98-8, These common heterocyclic compound, 5866-98-8, name is 2,6-Dichloro-3-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 30 Preparation of 6-Chloro-5-cyano-7-nitro-1,4-dihydroquinoxaline-2,3-dione To a stirred solution of 2,6-dichloro-3-nitrobenzonitrile (3.935 g, 18.13 mmol, Lancaster, used as received) in DMF (25 mL) at 70 C., an aqueous solution of sodium glycinate (1.760 g, 18.13 mmol, Aldrich, used as received) in water (25.0 mL) was added dropwise. The resulting solution was stirred at 70 C. for 48 h. The suspension was cooled to room temperature and the precipitated yellow solid was filtered, washed with chloroform (20 mL), and dried under vacuum to furnish 2.020 g (44%) of pure (1 H NMR) N-(3′-chloro-2′-cyano-6′-nitro)phenylglycine as a yellow powder. 1 H NMR (DMSO-d6): delta3.888 (d, 2H, J=3.9 Hz), 6.857 (d, 1H, J=9.0 Hz).
Statistics shows that 2,6-Dichloro-3-nitrobenzonitrile is playing an increasingly important role. we look forward to future research findings about 5866-98-8.
Reference:
Patent; State of Oregon, acting by and through the Oregon State Board of Higher Education, acting for and on behalf of the Oregon Health Sciences University and the University of Oregon, Eugene Oregon; Acea Pharmaceuticals, Inc.; The Regents of the University of California; US5631373; (1997); A;,
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