Electric Literature of 2469-99-0,Some common heterocyclic compound, 2469-99-0, name is 3-Oxobutanenitrile, molecular formula is C4H5NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirring solution of crude 8-fluoro-4-hy- drazinylquinoline (0.27 g, 1.5 mmol) and 3-oxo-butyroni- trile (0.15 g, 0.19 mmol) in pyridine (3 mE) was heated at 80 C. for 15 h. After cooling to room temperature, aqueous saturated sodium bicarbonate was added to the reaction mixture and extracted with dichioromethane (3x 10 mE). The combined organic layers were dried (Na2SO4), filtered, and concentrated in vacuo. The crude residue was used directly without thrther purification (0.14 g, 0.76 mmol, 50%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Oxobutanenitrile, its application will become more common.
Reference:
Patent; ChemoCentryx, Inc.; Cappel, Markus; (83 pag.)US2018/9797; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts