These common heterocyclic compound, 501-00-8, name is 2-(3-Fluorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 501-00-8
A solution of 2-(3-fluorophenyl)acetonitrile (5.0 g, 37.0 mmol) and methyl iodide (5.06 mL, 81.4 mmol) in THF (100 mL) at 00C was added sodium bis(trimethylsilyl)amide, 1.0M solution in THF (81.4 mL, 81.4 mmol). After addition, the mixture was stirred at 00C for 45 minutes. Then, H2O (100 mL) and EtOAc (100 mL) were added and the mixture was stirred at room temperature for 15 minutes. The organic layer was collected and the aqueous was extracted with EtOAc (1 x 100 mL). The combined organic extracts were dried over MgSO4, concentrated, and dried in vacuo to give 2-(3-fluorophenyl)-2-methylpropanenitrile as orange oil which was used without purification.
The synthetic route of 2-(3-Fluorophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; WO2009/137404; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts