Synthetic Route of 72115-09-4, The chemical industry reduces the impact on the environment during synthesis 72115-09-4, name is 5-Amino-2-bromobenzonitrile, I believe this compound will play a more active role in future production and life.
Step-1 : Synthesis of tert-butyl (4-bromo-3-cvanophenyl)carbamate. Di-tert-butyl dicarbonate (1.14g, 4.8mmol) was added to a solution of 5-amino-2- bromobenzonitrile (0.8g, 4mmol) and DMAP (0.58g, 4.8mmol) in DCM (20mL) and the resulting reaction mixture was stirred for 8h at room temperature. After completion of reaction, the reaction mixture was diluted with ice cold water and extracted with DCM (3×50 mL). The combined organic phase was washed with brine, dried over sodium sulphate, filtered and concentrated under reduced pressure. The residue was purified by 100-200 mesh silica column by eluting with 15% ethyl acetate -hexane to afford the title compound (lg, 83%). LCMS: m/z = 297.15 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-2-bromobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SAMAJDAR, Susanta; PODDUTOORI, Ramulu; MUKHERJEE, Subhendu; GOSWAMI, Rajeev; (174 pag.)WO2016/142855; (2016); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts