In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3598-13-8 as follows. Formula: C8H6ClNO
Starting Material 7: (6-Nitro-2-phenyl-benzoxazole-7-yl)-acetonitrile STR24 To a stirred suspension of potassium tert-butoxide (701 mg, 6.25 mmol) in DMF (6 mL) was added a solution of 6-nitro-2-phenyl-benzoxazole (500 mg, 2.08 mmol)(Starting Material 3) and 4-chlorophenoxyacetonitrile (366 mg, 2.19 mmol) (Aldrich) in DMF (20 mL) at -30 C. The mixture was then stirred at this temperature for 3 h and neutralized with aqueous 1N hydrochloric acid solution at 0 C. The aqueous layer was extracted with ethyl acetate. The combined extracts were dried over anhydrous magnesium sulfate and concentrated in vacuo to give a yellow solid. The crude product was purified by silica gel chromatography. (Yield 520 mg, 90%).
According to the analysis of related databases, 3598-13-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hoffmann-La Roche Inc.; US6153634; (2000); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts