Adding a certain compound to certain chemical reactions, such as: 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4592-94-3, Computed Properties of C9H6BrNO
1.0 g (2.1 mmol) of N(4-(4,4,5 ,5-tetramethyl- 1,3 ,2-dioxaborolane-2-yl)- 1 -tosyl- 1 H-pyffolo [2,3-b jpyridin-6-yl)cyclopropanecarboxamide prepared from the reaction formula 3 above was dissolved in DMF/H 20 = 2:1 solution, and then 0.6 g (2.5 mmol) of 3-(4-bromophenyl)-3-oxopropanenitrile, 0.2 g (0.2 mmol) of Pd(PPh ) and 0.15 mL of 2M K 2C0 aqueous solution were inserted thereinto and stuffed at 100 – 110C for 2 hours. Once the reaction was completed, the said mixture was cooled down at room temperature, then water was added thereto, and then an extraction using ethyl acetate was performed. After that, a solution extracted therefrom was dried by means of magnesium sulfate anhydrous and concentrated under reduced pressure, from which a residue was accordingly obtained. The residue was separated via NH-silica gel column chromatography (n-hexane / ethyl acetate = 5: 1), and N(4-(4-(2-cyanoacetyl)phenyl)- 1 -tosyl- 1 H-pyrrolo [2,3-b jpyridin-6-yl)cyclopropanecarboxamide was synthesized. A synthesized material was dissolved in MeOH/THF (1:1) solution, and then 2N sodium hydroxide aqueous solution was added thereto and stirred at 30 – 40C for 4 hours. Once the reaction was completed, the said mixture was cooled down to room temperature, and saturated ammonium chloride aqueous solution was added thereto while being stirred. A produced solid was filtered out, and finally a product, i.e., N(4-(4-(2-cyanoacetyl)phenyl)- 1 H-pyrrolo [2,3-b jpyridin-6-yl)cyclopropanecarboxamide was accordingly obtained.MS(ESI+) mlz 345 (M+H) +
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Bromophenyl)-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CJ HEALTHCARE CORPORATION; LEE, Hyuk Woo; JI, Mi Kyung; KIM, Seung Chan; YU, Ha Na; JUNG, Soo Yeon; PARK, Ji-Yeon; LEE, Ye-Lim; LEE, Ho-Youl; KI, So Young; KIM, Dongkyu; KIM, Myeongjoong; (410 pag.)WO2019/78619; (2019); A1;,
Nitrile – Wikipedia,
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