In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C12H6N2O
Under nitrogen (N2) atmosphere20 mL of chloroform (CHCl3)Compound2 mL of pyridine was added to a solution of 9-1 (0.409 g, 0.20 mmol) and Compound E (0.39 g, 2.0 mmol).After the mixed solution was refluxed under a nitrogen atmosphere for 24 hours,Extracted with dichloromethane (CH2Cl2) and washed with water. After solvent removal, methyl chloride (MC) /Recrystallize through methanol, the product is hexane,Purification was carried out by chromatography using a silica gel column using ethyl acetate and chloroform (CHCl 3) as eluent.The resulting solid was recrystallized through chloroform.Then, washed with methanol and dried under vacuum432 mg of compound 9 was obtained. (Yield 90%)
The synthetic route of 1080-74-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Chem, Ltd.; Im Bo-gyu; Jang Song-rim; Choi Du-hwan; Kim Ji-hun; (40 pag.)KR2019/117086; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts