Some common heterocyclic compound, 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, molecular formula is C7H5FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 5-Amino-2-fluorobenzonitrile
5-Amino-2-fluorobenzonitrile (1.50 g, 11.0 mmol) was dissolved in 10 mL of acetic acid.To this was added benzaldehyde (1.50 g, 14.1 mmol), and stirred at room temperature for 1 h.The reaction solution was cooled to 10-15 C, and sodium borohydride (0.44 g, 11.6 mmol) was added thereto.Stir for 10 min with heat, then alkalize with sodium carbonate solution, and extract with ethyl acetate.The organic layer was dried over anhydrous sodiumThe residue was recrystallized from ethyl acetate to give 5a, yield 80.2%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 53312-81-5, its application will become more common.
Reference:
Patent; Hangzhou Yirui Pharmaceutical Technology Co., Ltd.; Wang Xiaolu; Hu Yongzhou; Ye Qing; Hu Xiuai; (44 pag.)CN109651297; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts