Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1897-52-5, name is 2,6-Difluorobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 2,6-Difluorobenzonitrile
Example 2054-[2-(2,4-Diamino-quinazoIin-5-yloxy)-ethyl]-piperazine-l-carboxylic acid tert- butyl ester4-[2-(2-Cyano-3-fluoro-phenoxy)-ethyl]-piperazine-l-carboxylic acid tert-butyl ester t-butyl 4-(2-hydroxyethyl)piperazine-l-carboxylate (0.6 g; 2.6 mmol) was added to a suspension of sodium hydride (125 mg; 3.1 mmol) in 5 mL of anhydrous dimethylformamide at O0C. Mixture was then heated to 4O0C for 2 hours. Anion was cooled to room temperature and added to a O0C mixture of 2,6-difluorobenzonitrile in 5 mL of dimethylformamide. After 16 hours at room temperature, reaction was quenched over 2Og of ice, mixture was extracted 4 X 50 mL with ethyl acetate. Combined organics was washed with 6 X 40 mLs water, brine and dried over MgSO4. Crude oil was obtained after filtration and concentration. Material was purified by flash chromatography using 2-3.5% methanol/dichloromethane gradient to obtain 660 mg of title compound. (73% yield).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; deCODE Chemistry, Inc.; WO2008/16973; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts