Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 147754-12-9, name is 4-Fluoro-2-methylbenzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C8H6FN
4-Hydroxy-piperidine (1.05 g) was dissolved in 7 ml_ MTBE and 5 ml_ THF. Potassium tert-butylate (1.43 g) was added and the mixture was heated to 50 0C for 30 min. After cooling to rt, 4-Fluoro-2-methyl-benzonitrile (1.32 g) was added in portions. After stirring at rt for 2 h the reaction was quenched with water. The phases were separated and the aqueous layer was extracted with ethyl acetate (3x 10 ml_). The combined organic layers were washed with brine (10 mL), dried with MgSpsi4 and concentrated to yield 1.92 g (94percent) 2-Methyl-4-(piperidin-4-yloxy)-benzonitrile. Mass (ESI) (C13Hi6N2O): calcd. 216, found 217 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SANOFI-AVENTIS; WO2009/80335; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts