Reference of 1897-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1897-52-5, name is 2,6-Difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 4: 2-[4-(2,6-Difluorophenoxy)cycIohexylmethoxy]-6- fluorobenzonitrile (Method I)4-(2,6-Difluorophenoxy)cyclohexylmethanol (100 mg; 0.4 mmol) and 2,6- difluorobenzonitrile were combined in 3 mL of dimethylformamide under nitrogen flow and chilled to O0C. Potassium t-butoxide (56 mg; 1.2 mmol) was added in portions. Mixture warmed to room temperature. After 4 hours reaction was quenched with 3 mL of water and mixture was extracted with 3 X 8 mL of ethyl acetate. Combined organics were washed with 5 X 8 mL of water, once with brine and dried over MgSO4. Crude oil was purified via flash chromatography using 0-20% ethyl acetate in hexanes to give 95 mgs of title compound. (66% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Difluorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; deCODE Chemistry, Inc.; WO2008/16973; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts