Electric Literature of 6609-56-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6609-56-9 as follows.
To a nitromethane (0.1 mL) solution of 4-methoxybenzonitrile (1f) (30 mg, 0.225 mmol) were addedH2O (1.0 mL), DBU (69 mg, 0.436 mmol), copper (I) iodide (9 mg, 0.0451 mmol), cesium (I)carbonate (37 mg, 0.113 mmol) at room temperature. The reaction mixture was heated at 100 °C for2 h and then poured into water (50 mL). The organic layer was separated and the aqueous layer wasextracted with AcOEt. The combined organic layer was dried over MgSO4. The solvent wasremoved under reduced pressure. The residue was purified by preparative TLC on silica gel elutingwith AcOEt-n-hexane (1:1) to give 2-methoxybenzamide (2f)S5 (17 mg, 50percent) as pale yellow powders.mp 123-125 °C,
According to the analysis of related databases, 6609-56-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kuwabara, Jun; Sawada, Yoshiharu; Yoshimatsu, Mitsuhiro; Synlett; vol. 29; 15; (2018); p. 2061 – 2065;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts