Adding a certain compound to certain chemical reactions, such as: 108168-88-3, name is N-(tert-Butyl)-2-cyanoacetamide, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108168-88-3, COA of Formula: C7H12N2O
Into a 8-mL sealed tube, was placed 3-(2-fluoro-5-formylphenoxy)propanoic acid (20 mg, 0.09 mmol, 1.00 eq.), methanol (0.25 mL), N-tert-butyl-2-cyanoacetamide (13.2 mg, 0.09 mmol, 1.00 eq.), CH3COONH4 (36.3 mg, 0.47 mmol, 5.00 eq.). The resulting solution was stirred for 30 min at 60 C. The reaction was then quenched by the addition of 10 mL of water. The resulting solution was extracted with 3×10 mL of ethyl acetate and the organic layers combined and dried over anhydrous sodium sulfate and concentrated under vacuum. The crude product was purified by Flash-Prep-HPLC with the following conditions (CombiFlash-l): Column, C18 silica gel; mobile phase, FbC):ACN=99: l increasing to FLO: ACN= 1 :99 within 100 min; Detector, UV 254 nm. This resulted in 5 mg (16%) of 3-[5- [2-(tert-butylcarbamoyl)-2- cyanoeth-l-en-l-yl]-2-fluorophenoxy]propanoic acid as a white solid.
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Reference:
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy Duncan; BRAMELD, Kenneth Albert; GOLDSTEIN, David Michael; (171 pag.)WO2019/99576; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts