1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile
As it is shown in Scheme 3 above, 3,4,5,6-tetra-chloride in a nitrogen gas rope phthaloyl nitrile (tetrachlorophthalonitrile) (5.0mmol), 2,5- di (di) – [tert (tert) – butyl (butyl ) -4-methoxyphenol (methoxyphenol) (1.5 eq.), potassium carbonate (K 2 CO 3) (10 equivalents) of anhydrous (anhydrous) dissolved in 30ml DMF after 12 hours at 80 dongan reflux (reflux) thereby.After completion of reaction, the reaction solution into ice water slowly degrades (ice water) (dropwise). Then, methylene chloride: then extracted three times, magnesium sulfate (MgSO with (methylene chloride MC) 4 is removed by passing the water in) and evaporated (evaporation).Then, the obtained phthalonitrile (phthalonitrile) precursor to the dried crude product (crude product) was purified by column chromatography (column chromatography).
The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Display Co., Ltd; Seoul National University Industry-Academic Cooperation Foundation; Kim, Young Hun; Ahn, Byung Gun; Han, Sang Hun; Kim, Jae Pil; Choe, Jun; Namgung, Jinung; (13 pag.)KR2016/5258; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts