Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 185836-35-5, name is 4-(Benzyloxy)-2-fluorobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 185836-35-5
A solution of [(R)- (-)-L-AMINO-PROPAN-2-OL] (389 g, 5.19 mol) in dimethyl sulfoxide (600 mL) was added to a solution of the product from Step A (786 g, 3.46 mol), basic alumina (786 g), and [4A] molecular sieves (131 g). The stirred mixture was heated at 110- 140 oC for 24 h, cooled and filtered, the filter-aide was washed with 10 L of 4: 1 ether- ethyl acetate followed by 4 L of 3: 2 ethyl acetate-hexane. The organic washes were extracted with water (5 L) and the aqueous phase was extracted with 25% ethyl acetate- hexane (4 x 2 L). The combined organic phases were washed with water and brine, dried over sodium sulfate, concentrated to about 3 L and allowed to stand for 48 h. The precipitated solid was collected by filtration, washed with hexane, and vacuum-dried to provide the desired product in two crops (619 g and 86 g). The concentated supernatant was applied to a 5 kg silica gel pad and eluted with a gradient of 10-50% ethyl acetate- hexane to give, after concentration in vacuo, additional product (119 g): total yield was 791 g [(8 1 %).]
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ALCON, INC.; WO2003/101379; (2003); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts