Related Products of 4475-95-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4475-95-0 name is 2-Amino-2-methylbutanenitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a mixture of carboxylic acid (1 mmol), EDC·HCl (1.2 mmol) and HOBt (1.2 mmol) in dry dichloromethane (10 mL) was added a mixture of amine (1 mmol) and triethyl amine (1.5 mmol) in dichloromethane (5 mL) at 0 C. The mixture was stirred at room temperature till the completion of reaction (judged by TLC). The reaction mixture was diluted with additional DCM (20 mL). The organic layer was washed with water, brine and dried (Na2SO4). Concentration and purification over silica gel (100-200 mesh) afforded the desired compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-2-methylbutanenitrile, and friends who are interested can also refer to it.
Reference:
Article; Sasmal, Pradip K.; Talwar, Rashmi; Swetha; Balasubrahmanyam; Venkatesham; Rawoof, Khaji Abdul; Neelima Devi; Jadhav, Vikram P.; Khan, Sanjoy K.; Mohan, Priya; Srinivasa Reddy; Nyavanandi, Vijay Kumar; Nanduri, Srinivas; Shiva Kumar; Kannan; Srinivas; Nadipalli, Prabhakar; Chaudhury, Hira; Sebastian; Bioorganic and Medicinal Chemistry Letters; vol. 21; 16; (2011); p. 4913 – 4918;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts