Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 120351-94-2, name is 3-(2-Aminoethoxy)benzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C9H10N2O
Step 1 Synthesis of N-[2-(3-cyanophenoxy)ethyl]-(1S)-10-camphorsulfonamide: 700 mg (4.32 mmol) of 3-(2-aminoethoxy)benzonitrile was dissolved in 20 ml of DMF. 0.75 ml (4.32 mmol) of diisopropylethylamine and a solution of 1.08 g (4.32 mmol) of (1S)-(+)-10-camphorsulfonyl chloride in 5 ml of DMF were added to the solution at 0C, and they were stirred for 4 hours. The crude product was obtained by the same isolation process as that of step 1 in Example 1 with ethyl acetate as the extractant. After the purification by the silica gel column chromatography, the title compound was obtained. Yield: 1.41 g (3.75 mmol) (87 %) MS (ESI, m/z) 377 (MH+) H-NMR (CDCl3) delta 0.88 (3H, s), 1.04 (3H, s) 1.47 (1H, ddd), 1.89-2.15(5H, m), 2.33 (1H, td), 2.98 (1H, d), 3.46 (1H, d), 3.59 (2H, dt), 4.14 (2H, t), 6.00(1H, t), 7.15 (1H, d), 7.18(1H, s), 7.26 (1H, d), 7.39 (1H,t)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Ajinomoto Co., Inc.; EP976722; (2000); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts