Reference of 1897-52-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1897-52-5 as follows.
To the suspension of 2,6-difluorobenzonitrile (20.0 g, 144 mmol), K2CO3 (40.00 g, 289 mmol) in dimethyl sulfoxide (80 mL), morpholine (13.20 g, 152 mmol) was added slowly. The mixture was heated at 90C for 3 hours. After completion of the reaction as indicated by TLC, the reaction mixture was carefully poured into stirring water (500 mL), then filtered. The filter cake was washed with water and dried to afford 18.00 g of 2-fluoro-6-morpholinobenzonitrile: Yield 90.0%; m.p. 69-70 C; IR (numax,cm-1) KBr: 3096 (Ar), 2869 (CH2), 2226 (CN), 1605 (Ar), 1567 (Ar), 1082 (O); 1H NMR (600 MHz, CDCl3) delta 7.42-7.50 (m, 1H), 6.73-6.80 (m, 2H), 3.87 (m, 4H), 3.24 (m, 4H); MS(ESI) m/z: 207.3 [M + H]+; Anal. calcd for C11H11FN2O: C, 64.07; H,5.38; N, 13.58; found: C, 63.99; H, 5.42; N, 13.63%.
According to the analysis of related databases, 1897-52-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Lu, Jiu-fu; Zhou, Xing-long; Xu, Yu-hang; Yue, Si-yu; Ji, Xiao-hui; Zheng, Nan; Jin, Ling-xia; Journal of Chemical Research; vol. 41; 9; (2017); p. 526 – 528;,
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