In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 654-70-6 as follows. Formula: C8H5F3N2
Example 43 (General Procedure (D)) 3-Tert-Butyl-5-Chloro-N-(4-Cyano-3-Trifluoromethyl-Phenyl)-2-Hydroxy-6-Methyl-Benzamide. The title compound was prepared from 5-chloro-3-tert-butyl-6-methylsalicylic acid and 4-cyano-3-trifluoromethylanilin. 1H-NMR: (CDCl3, 400 MHz): delta ppm 1.40 (s, 9 H) 2.53 (s, 3 H) 7.39 (s, 1 H) 7.66 (s, 1 H) 7.86 (d, J=8,3 Hz, 1 H) 8.97 (d, J=8,3 Hz, 1 H) 8.05 (s, 1 H) 9.05 (s, 1H).
According to the analysis of related databases, 654-70-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hansen, Birgit Sehested; Hansen, Thomas Kruse; Tullin, Soren; Colding-Jorgensen, Morten; US2004/138301; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts