Synthetic Route of 67832-11-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67832-11-5 as follows.
4-Bromo-2-bromomethylbenzonitrile (TJA01043) C8H5Br2N MW 274.94. 4-Bromo-2-methylbenzonitrile (5.00 g, 25.5 mmol), N-bromosuccinimide (4.99 g, 28.1 mmol), benzyl peroxide (0.198 g, 0.816 mmol) and carbon tetrachloride (100 mL) were loaded to a r.b. flask and set to reflux (79 C) for 6 h. Once cooled the succinimide was filtered off and carbon tetrachloride removed via a dry ice-acetone cooled rotary evaporator. The residues were dissolved in dichloromethane (100 mL) and washed with distilled H2O (50 mL x 3) and brine (50 mL x 2). Dried over Na2SO4 and solvent removed in vacuo to leave yellow residues. Column chromatography (hexane/dichloromethane 60:40) eluted the title compound as a yellow solid. Recrystallisation (cyclohexane) gave a white crystalline solid (5.07 g, 73 %), mp 61.7-77.2 0C;
According to the analysis of related databases, 67832-11-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; STERIX LIMITED; WO2007/68905; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts