Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 215800-25-2, name is 2-(4-Bromo-3-methylphenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., name: 2-(4-Bromo-3-methylphenyl)acetonitrile
A mixture of 2-(4-bromo-3 -methylphenyl)acetonitrile (1 .50 g, 7.14 mmol, 1.0 eq), (2-fluorophenyl)boronicacid (1.19 g, 8.56 mmol, 1.2 eq), CsF (2.38 g, 15.70 mmol, 2.2 eq), Pd(PPh3)4 (0.41 g, 0.35 mmol, 0.05 eq) in DMF (15 mL) was stirred at 90 C under nitrogen atmosphere for 18 h. After complete consumption of starting material, the mixture was cooled to ambient temperature and partitioned between water and ethyl acetate. The organic extract was separated and the aqueousextract was again extracted with ethyl acetate. The combined organic extract was washed with brine, dried over anhydrous Na2SO4, filtered and solvents evaporated from the filtrate under reduced pressure to obtain a crude, which was purified by flash chromatography on silica gel, 23 0-400 mesh, using gradient of ethyl acetate in hexanes as eluent to obtain 2-(2?-fluoro-2- methyl-[1,1?-biphenyl]-4-yl)acetonitrile as yellow oil, yield (1.12 g, 70%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 215800-25-2.
Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; BARTA, Thomas, E.; BOURNE, Jonathna, William; MONROE, Kyle, D.; MUEHLEMANN, Michael, M.; PANDEY, Anjali; BOWERS, Simeon; (59 pag.)WO2017/34990; (2017); A1;,
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