6330-25-2, name is 2-Cyano-N-methyl-acetamide, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C4H6N2O
Step 3To a 10 ml seal tube was added 5-(7-pivaloyl-5-((2-trimethylsilyl)ethoxy)methyl)-5H- pyrrolo[2,3-b]pyrazin-2-ylamino)thiophene-2-carbaldehyde (0.150 g, 0.000327mole), 2-cyano – N,N- dimefhylacetamide (0.183 g, 0.00163 mole) and ethanol (5 ml) followed by addition of piperidine acetate (3.3 M solution in water) (1.5 ml, 0.00495 mole) at RT. The tube was sealed and the reaction mixture was heated at 80 C for 24 hr. After completion of reaction, ethanol was distilled out, the reaction mixture was diluted with ethyl acetate. The organic layer was separated and washed with water, dried over sodium sulphate and concentrated to give the desired crude product which was purified using column purification by eluting the compound with 35% ethyl acetate in hexane to yield 1 10 mg of 2-cyano-N,N-dimethyl-3-(5-(7-pivaloyl-5-((2- trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)thiophen-2-yl)acrylamide
The synthetic route of 6330-25-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRINCIPIA BIOPHARMA INC.; GOLDSTEIN, David Michael; BRAMELD, Kenneth Albert; VERNER, Erik; WO2012/158785; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts