Electric Literature of 35704-19-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35704-19-9, name is N-(4-Cyanophenyl)acetamide, This compound has unique chemical properties. The synthetic route is as follows.
In a 50-mL round bottom ask equipped with a magnetic stirrer and an oil-bath, a mixture of p-cyanoacetanilide (2.93 g, 18.3 mmol), sodium azide (2.37 g, 36.5 mmol), and ammonium chloride (0.53 g) as a catalyst was dissolved in 20 mL of DMF and reuxed for 12 h. The reaction progression was controlled by thin layer chromatography (TLC) with the solvent mixture of EtOAc:cyclohexane:methanol/8:10:2 (V/V). The reactioncolor turned pale yellow and the solvent was removed under reduced pressure by a rotary evaporator. The viscous residue was put on an ice-bath, hydrochloric acid (2 M) was added dropwise until the pH was 1, and the white solid was precipitated, filtered out, and recrystallized with the mixture of methanol and water (3.1 g,84% yield). Colorless solid, mp 289{300 C; FT IR (KBr) 3311, 3267 (NHCO), 3195, 3129, 3069, 2985, 2920, 2854,2706, 2615, 2471 (N4 H, CH-ar.), 1678 (C=O) cm1 ; 1H NMR (400 MHz, DMSO-d6) 2.09 (s, 3H, CH3) ,3.44 (bs, 1H), 7.78 (d, 2H, J = 8.3 Hz, CH-ar.), 7.96 (d, 2H, J = 8.3 Hz, CH-ar.), 10.26 (s, 1H, NHCO); 13CNMR (100 MHz, DMSO-d6) : 24.2 (CH3) , 118.4 (C-ar.), 119.2 (CH-ar.), 127.7 (CH-ar.), 141.9 (C-ar.), 155.0(C-tetrazole), 168.9 (C=O).
The chemical industry reduces the impact on the environment during synthesis N-(4-Cyanophenyl)acetamide. I believe this compound will play a more active role in future production and life.
Reference:
Article; Pesyan, Nader Noroozi; Soleimani, Davoud; Jazani, Nima Hosseini; Turkish Journal of Chemistry; vol. 39; 5; (2015); p. 998 – 1011;,
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