Related Products of 133116-83-3, A common heterocyclic compound, 133116-83-3, name is 2-Fluoro-6-(trifluoromethyl)benzonitrile, molecular formula is C8H3F4N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step a: Preparation of 1-(2-cyano-3-trifluoromethylphenyl)piperazine A mixture of 3 g (15.8 mmol) of 2-fluoro-6-trifluoromethylbenzonitrile, 7.5 g (87 mmol) of piperazine and 24 mL of dioxan is heated to reflux for 5 hours. The reaction medium is concentrated in a vacuum and the residue is taken up with ethyl acetate. After washing with water, the organic phase is dried on magnesium sulphate, filtered and concentrated. The product crystallises at ambient temperature. After drying in a vacuum, 3.6 g of 1-(2-cyano-3-trifluoromethylphenyl)piperazine is obtained which is used as such in the subsequent syntheses. Rf: 0.65 dichloromethane/methanol/ammonia 90/10/1
The synthetic route of 133116-83-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOPROJET; US2008/214542; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts