Reference of 179898-34-1, A common heterocyclic compound, 179898-34-1, name is 3-Bromo-5-fluorobenzonitrile, molecular formula is C7H3BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2-(pyridin-2-yl)-4,5,6,7-tetrahydrooxazolo[5,4-c]pyridine (20 mg, 0.1 mmol) in toluene was added 3-bromo-5-fluorobenzonitrile (30 mg, 0.15 mmol), Cs2CO3 (65 mg, 0.2 mmol), Pd(OAc)2 (1 mg, cat.), and Xantphos (2 mg, cat.). The mixture was heated to 1000C and stirred overnight. The mixture was cooled, dissolved in MeOH, and filtered. The filtrate was concentrated and the residue was purified by preparative TLC to afford 3-fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo- [5,4-c]pyridin-5(4H)-yl)benzonitrile (10 mg, 31%) as a yellow solid. 1H NMR (400 MHz, CDCl3): delta 8.68 (d, IH); 8.05 (d, IH), 7.77 (t, IH), 7.32 (t, IH), 6.90 (s, IH), 6.75 (m, 2H), 4.40 (s, 2H), 3.68 (t, 2H), 2.80 (t, 2H); LC/MS: m/e = 321 (M+H)+.
The synthetic route of 179898-34-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
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