Some common heterocyclic compound, 1897-52-5, name is 2,6-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H3F2N
Take a 500mL eggplant bottle,20.0 g of 2,6-difluorobenzonitrile was added,Anhydrous potassium carbonate 40.0 g and dimethyl sulfoxide 200 mL,Warming up to 90 C,Slowly drip morpholine 13.20g with stirring.TLC detects the progress of the reaction,After the reaction is completed, the reaction solution is naturally cooled to room temperature.Pour into the stirring ice water solution,18.0 g of white solid powder was precipitated.That is, 2-fluoro-6-morpholinylbenzonitrile (a).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1897-52-5, its application will become more common.
Reference:
Patent; Liaoning University; Liu Ju; Chen Ye; Gong Yilin; Wang Yang; Ding Shi; Shi Jiantao; Cao Shuwen; (12 pag.)CN108558763; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts