Related Products of 6136-68-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6136-68-1 as follows.
3-Acetylbenzonitrile (5g, 34.4 mmol) is added to a flask containing (R)-(+)-2-Methyl-2- propanesulfmamide (3.48g, 28.7 mmol) and Titinium (IV) ethoxide (13.1 g, 57.4 mmol) in THF (70 mL) and the reaction mixture heated at 75C overnight. The reaction mixture is cooled (-48C) and L-Selectride (1M solution in THF, 57.4 mL) added dropwise over lhour. The reaction stirred for 2hrs and allowed to warm to room temperature. The reaction is then cooled to 0C and methanol (3 mL) added. Brine (150 mL) is added with stirring and the suspension filtered through celite. The crude material is extracted with ethyl acetate, dried (MgS04), filtered and evaporated under vacuum. The cruse is purified by column chromatography eluting with heptane-ethyl acetate to give N- |Y 1 S)- 1 -(3 -cyanophenyDethyl] – 2 -methyl- |”S(R)]- 2-propanesulfmamide (78 %)MS: 251 (M+H)lB NMR (300 MHz, CDC13): delta = 1.22 (s, 9H), 1.54 (d, 3H), 3.36 (bs, 1H), 4.55-4.7 (m, 1H), 7.43 (d, 1H), 7.46 (d, 1H), 7.56-7.6 (m, 2H), 7.64 (s, 1H).
According to the analysis of related databases, 6136-68-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANOFI-AVENTIS; VANDEUSEN, Christopher L.; WEIBERTH, Franz J.; GILL, Harpal S.; LEE, George; HILLEGASS, Andrea; WO2011/44307; (2011); A1;,
Nitrile – Wikipedia,
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