Synthetic Route of 2941-29-9, A common heterocyclic compound, 2941-29-9, name is Cyclopentanone-2-carbonitrile, molecular formula is C6H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[00688] Intermediate 74e: benzyl N-{4-[(2-cyanocyclopent-1 -en-I -yI)(cyanomethyl)am ino]-2- (trifluoromethoxy)phenyl}carbamate[00689] p-Toluenesulfonic acid monohydrate (0.08g, 0.43mmol) was added to a solution of benzylN-[4-(cyanomethylamino)-2-(trifluoromethoxy)phenyl]carbamate (1 .57g, 4.3mmol) and IntermediateI (0.52g, 4.73mmol) in toluene (4OmL). The resulting solution was heated to reflux for 5 hours under Dean-Stark conditions, the mixture was then cooled to room temperature and allowed to stand overnight. The solution was transferred to a separating funnel, washed with sat. aq. NaHCO3 solution (5OmL) and the aqueous washed with EtOAc (3 x 5OmL). The organic layers werecombined, washed with brine (5OmL), dried over Na2504 and the solvent removed in vacuo to give benzyl N-{4-[(2-cyanocyclopent-1 -en-i -yl)(cyanomethyl)amino]-2- (trifluoromethoxy)phenyl}carbamate as a brown oil (2.02g, 4.3mmol, 100percent yield) which was used as is in the next step without further purification.MS Method 2: RT: 1.90 mi m/z = 457.2 [M+H]
The synthetic route of 2941-29-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; REDX PHARMA PLC; ARMER, Richard; BELFIELD, Andrew; BINGHAM, Matilda; JOHNSON, Alice; MARGATHE, Jean-Francois; AVERY, Craig; HUGHES, Shaun; MORRISON, Angus; (278 pag.)WO2016/51193; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts