These common heterocyclic compound, 72291-30-6, name is Methyl 2-cyano-2-methylpropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Methyl 2-cyano-2-methylpropanoate
50L adding glass cauldron 25L methanol, add 2.20 kg potassium hydroxide (39.4mol), stirring then after cooling to room temperature, dropping 5.00kg2-cyano-2-methyl propane acid methyl ester (39.4mol), stirring reaction after dropping 2h; reaction the fluid turns on lathe dry, solid with a small amount of anhydrous ethanol after washing, 50 C drying, obtain 5.53kg2-cyano-2-methyl propane acid potassium, molar yield 93%.
The synthetic route of Methyl 2-cyano-2-methylpropanoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hefei Leaf Biotechnology Limited; Deng, Jin; Wang, Peng; Fu, Yao; Ding, Fan; Xu, Qiang; Xu, Hai; Yu, Sanxi; Ding, Feijiao; Wu, Jiangjiang; Huang, Ligang; Xu, Shengchun; (8 pag.)CN105541594; (2016); A;,
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