Related Products of 22364-68-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22364-68-7 name is 2-(o-Tolyl)acetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 6: (E/Z)-2-(2-methylcvclohexylidene)-2-o-tolylacetonitrile To the stirred mixture of 2-methylcyclohexanone (12.3 g, 0.11 mol) and o-methyl benzyl cyanide (13.1 g, 0.10 mol) is added sodium methoxide (30% in MeOH, 18.5 ml, 0.10 mol) during 15 min and the resulting brown mixture is heated under stirring to 600C (oilbath) for 3 h and 8O0C for further 10 h. The mixture is diluted with toluene, the organic layer washed with brine/H2O 1 :1 and dried over MgSO4. The solvent is removed under reduced pressure and the residue distilled over a short-path apparatus at 0.05 mbar. The fraction distilling at 96-1240C is collected (5.4 g) and further purified by EPO
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(o-Tolyl)acetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; GIVAUDAN SA; WO2006/133592; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts